Danazol in Idiopathic Sideroblastic Anemia
نویسندگان
چکیده
منابع مشابه
Natural history of idiopathic refractory sideroblastic anemia.
We analyzed the natural history of idiopathic refractory sideroblastic anemia (IRSA) in 37 patients studied between 1969 and 1986. Although erythroid abnormalities were prominent in all, 12 patients also showed involvement of the granulocytic and/or megakaryocytic cell lines, and nonrandom chromosomal aberrations were observed in five of 23 patients studied for such defects. Measurements of ery...
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In order to determine the prognostic significance of thrombocytosis in idiopathic sideroblastic anemia, the clinical courses of 17 patients were reviewed. Six patients (36%) had thrombocytosis, and none developed acute leukemia. Nine patients (53%) had normal platelet counts, and one developed acute leukemia. Two patients (12%) were thrombocytopenic, and one died of acute leukemia. There was li...
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Three patients with idiopathic sideroblastic anemia of variable duration developed acute leukemia. In two the leukemia was morphologically and histochemically myeloblastic, in one lymphoblastic. With combination chemotherapy remission was achieved in all three. The remission inductions were complicated by long periods of bone marrow suppression and the duration of remissions was brief (3, 2 and...
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Any compendium of facts and factors that can weight or cast doubt on the quantitative significance of serum fernitin measurement as a measure of iron stores is not complete without mention of immunologic nonidentical isofernitins. Liven on spleen fernitin is used as the refenence standard and for the production of antibody, yet there is abundant evidence that the ferritin in serum is immunologi...
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BACKGROUND AND OBJECTIVE Severe anemia is an important problem in patients with idiopathic myelofibrosis (IM). When other therapeutic measures are unsuccessful or not applicable, 40-50% favorable responses are obtained with androgen therapy. Oxymetholone is the drug usually employed, but good results have also been reported with danazol, although the experience is limited to a few patients. The...
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ژورنال
عنوان ژورنال: Acta Haematologica
سال: 1988
ISSN: 0001-5792,1421-9662
DOI: 10.1159/000205814